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Rainbow bookends target1/14/2024 ![]() ![]() This is accomplished by fusing the extracellular domain of PD-1 (PD-1 ex), which naturally holds a low affinity to PD-L1, to an αCD3.αCD33 BiTE-like scaffold. We developed a bifunctional checkpoint inhibitory T cell–engaging (CiTE) antibody that combines T-cell redirection to CD33 on AML cells with locally restricted immune checkpoint blockade. PD-1 and PD-L1 blocking agents may counteract T-cell dysfunction, however, at the expense of broadly distributed immune-related adverse events (irAEs). Yet, T-cell activation is correlated with upregulation of programmed cell death-ligand 1 (PD-L1) and other inhibitory checkpoints on AML cells that confer adaptive immune resistance. ($7.The CD33-targeting bispecific T-cell engager (BiTE) AMG 330 proved to be highly efficient in mediating cytolysis of acute myeloid leukemia (AML) cells in vitro and in mouse models. Target's Room Essentials line has everything from colanders to mixing bowls in a rainbow of pink, turquoise, lime or blue heat-resistant synthetics. The collection comes in cheerful hues like lemon, raspberry, lilac and spring green. Lifefactory goes one step further in the category with not only an adult bottle, but baby bottles and sippy cups. Bkr donates to cancer research as well as clean water projects in Africa. San Francisco-based Bkr makes a glass water bottle with a silicone sleeve, in hip shades like Jet black, Rocket red, Julep teal and Space indigo. Sky-blue spatulas, tangerine whisks - just about any kitchen tool can be found in a fun, friendly hue. The same characteristics make it big with kitchen and home designers, who also appreciate that it's dishwasher-friendly. Whether it's a Kitchenaid blender in hot pink or a set of Rachael Ray's sunny orange cookware, there's more color in good-quality, functional, synthetic-material gadgets than ever before.įlexible silicone has fans in fashion, where accessories designers love its pliability, color friendliness and soft feel. But today's cook has a paintbox of hues available when buying mixing bowls, cooking tools and utensils. There was a time when kitchen cupboards and drawers were full of boring basics. It'll survive indoors or out, and comes in several shades including pale yellow, black and zinc white. ![]() Kartell also has manufactured Starck's Bubble chair, a cartoonishly scaled piece that looks like an oversize upholstered chair but is made entirely out of polyethylene. There's a wide range of colorful transparent pieces in the company's collection. (Italian design powerhouse Kartell has frequently dominated the synthetic materials marketplace, with "wow" factor pieces such as Philippe Starck's Louis Ghost chair and Ferruccio Laviani's Bourgie lamp. The company will custom tint, however designer Benjamin Noriega-Ortiz likes to use a milky white acrylic for an ethereal quality. The material works well in small spaces - entryways, boudoirs, small living rooms - because it's nearly invisible. Plexi-craft in New York stocks a wide array of furniture in crystal-clear acrylic. You'll find clear acrylic cube tables, too, in modern takes on classic architectural design. Their playful acrylic bookends come in a variety of silhouettes including cats, roosters, dogs, flowers, even a pair of shapely female legs. The duo's curvy acrylic vases and rippled bowls, done in neon hues, are décor dancing. ![]() Two Palm Springs, Calif., designers - Larry Abel and Raymond McCallister - run Art Style Innovation, a fun factory of whimsical takes on vintage and modern décor. Using heat, they can be stretched and molded without losing clarity, and joints are heat fused rather than glued or screwed, which makes a finished piece virtually seamless. The product range in colorful plastics is expanding, with great shapes and fun hues.įrom a crafting standpoint, acrylics are easy to work with. ![]() The newest ones are a designer's delight: They're malleable, strong, lightweight and take color easily. Manufacturers of home goods are quick to adopt innovative materials and technology, and synthetics have long been a favorite. And those acrylic salad bowls and patio chairs? World War II fighter pilots needed safer canopies, and Plexiglas was the answer. Your salad spinner's made of the same sort of silicone rubber developed to make Neil Armstrong's moon boot. Next time you're having a backyard barbecue or going mod with some new furniture, thank science. ![]()
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